Prednisolone: ​​composition, indications, dosage, side effects

Composition and form of release

Prednisone is made in tablets, solution for injection and ointment. The main ingredient is prednisone.


Prednisolone is used to treat adrenal cortex insufficiency, congenital adrenal hyperplasia, subacute thyroiditis, contact dermatitis, serum sickness, persistent or seasonal allergic rhinitis, angioedema, rheumatoid arthritis, ankylosing dermatitis, pyloric myocarditis, red ankylosis, red ankylosis, sclerodermatitis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, red ankylosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, pyloric fibrosis, papillary fibrosis, red pulmonary fibrosis, cystic fibrosis, red pulmonary fibrosis, red blood cell count periarteritis nodosa, recurrent polychondritis, systemic vasculitis, exfoliative dermatitis, severe seborrheic dermatitis, pemphigus, severe psoriasis. Its use is advisable in the treatment of autoimmune diseases, inflammatory joint lesions, eye diseases, respiratory and liver lesions, as well as cardiovascular, neurological and oncological diseases.

Prednisone is often used in transplantology to prevent the occurrence of rejection reactions.


Prednisolone is not prescribed if the patient has a peptic ulcer of the stomach or duodenum, kidney failure, osteoporosis, predisposition to thromboembolism, severe arterial hypertension, herpes zoster, chickenpox, and Cushing’s syndrome.

Pregnancy and lactation

Prednisolone can be used in the treatment of pregnant women, but only for strictly medical reasons and under the supervision of a doctor.

When using the drug in the treatment of women at the stage of lactation, it is necessary to make sure that the breast-fed child does not suffer from hyperbilirubinemia.

Dosage and administration

Prednisolone tablets are taken orally without chewing. In each specific case, the dose of the drug is selected individually. When choosing a dose, the circadian rhythm of glucocorticoid secretion in the body must be taken into account, in connection with this, 2/3 of the daily dose or the entire dose is recommended to be taken in the morning (8 hours in the morning) and 1/3 of the dose in the evening. When the drug is canceled, a gradual decrease in dosage occurs until it is completely stopped.

In adult patients in the treatment of acute conditions, the drug is prescribed in a starting dose of 20 to 30 mg, the daily maintenance dose is from 5 to 10 mg. If necessary, the initial daily dose may be from 15 to 100 mg.

For children, the drug is prescribed 1 or 2 mg per kg body weight, and the maintenance dose for children is from 300 to 600 micrograms per kg body weight of the child. The daily dose in the treatment of children should be divided into 4 or 6 doses.


The risk of an overdose of prednisone increases significantly with prolonged use of the drug in high doses. With an overdose in patients, an increase in blood pressure, the occurrence of peripheral edema and an increase in side effects are observed.

To stabilize the condition, it is recommended to temporarily stop taking the drug and adjust the dosage.

Side effects

With prolonged use of prednisone, obesity, hemorrhagic pancreatitis, menstrual irregularities, ulceration of the digestive tract, decreased immunity, increased blood coagulation, mental disorders and withdrawal syndrome are possible.

Terms and conditions of storage

Prednisolone is stored in a place protected from light and not accessible to children.

The shelf life of the drug is 2 years.

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